Public Assessment Report Decentralised Procedure Livazo 1mg, 2mg and 4mg film-coated tablets Alipza 1mg, 2mg and 4mg film-coated tablets Vezepra 1mg, 2mg and 4mg film-coated tablets Pitavastatin 1mg, 2mg and 4mg film-coated tablets

Public Assessment Report Decentralised Procedure Livazo 1mg, 2mg and 4mg film-coated tablets Alipza 1mg, 2mg and 4mg film-coated tablets Vezepra 1mg, 2mg and 4mg film-coated tablets Pitavastatin 1mg, 2mg and 4mg film-coated tablets

Efficacy of brexpiprazole in patients with acute schizophrenia: Review of three randomized, double-blind, placebo-controlled studies

Brexpiprazole, a serotonin-dopamine activity modulator, is a partial agonist at 5-HT1A and dopamine D2 receptors, and antagonist at 5-HT2A and noradrenaline α1B and α2C receptors, all at similar potency. Efficacy of brexpiprazole was evaluated in patients with acutely exacerbated schizophrenia in three short-term, randomized, double-blind, placebo-controlled studies. In a Phase 2 study, patient...

The Effect of Core Surface Tension on Roughness of Film - Coated Tablets

The arithmetic mean roughness, Ra, values were determined by scanning electron microscopic technique of different core models (furazolidone, nitrofurantoin and acetyl salicylic acid), coated by HPMC film forming solution containing 10 wt% of various molecular weight PEGs. The results showed that both plasticizer molecular weight and core surface free energy could have a significant influence on...

Possible Central Role of Oxytocin in Neurobehaviour of Male Rats and Mice

Oxytocin a nonapeptide of molecular mass 1007 d a ltons secreted in the paraventricular and supraoptic nuclei of the hyp o t h a la mu s . Its receptors are widely dis tributed in the central nervous sys tem. However, the behavioral effect s o f c entrally adminis tered oxytocin have received little attention because of availability of less information about its role in male psychobehavior. In ...

The Effect of HLB on the Release Profile of Atenolol from Ethyl Cellulose-coated Tablets

It is possible to alter the permeability of ethyl cellulose membrane with certain materials such as surfactants. In this study the effect of surfactant concentration and different HLB values on the release rate of atenolol from ethyl cellulose-coated tablets was evaluated. The results showed that when the concentration of surfactant increased, the rate of drug release also increased. The kineti...